Wiskott-Aldrich syndrome protein

WAS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CEE, 1EJ5, 1T84, 2A3Z, 2K42, 2OT0
Identifiers
Aliases	WAS, SCNX, THC, THC1, WASPA, WASp, IMD2, Wiskott-Aldrich syndrome
External IDs	OMIM: 300392 MGI: 105059 HomoloGene: 30970 GeneCards: WAS
Gene ontology Molecular function • phospholipase binding • GTPase regulator activity • SH3 domain binding • protein binding • identical protein binding • actin binding • protein kinase binding • small GTPase binding • Rac GTPase binding Cellular component • cytoplasm • cell-cell junction • vesicle membrane • actin cytoskeleton • extracellular exosome • cytoskeleton • cytosol • actin filament • intracellular Biological process • defense response • Fc-gamma receptor signaling pathway involved in phagocytosis • protein complex assembly • actin filament organization • negative regulation of cell motility • blood coagulation • positive regulation of Arp2/3 complex-mediated actin nucleation • actin filament-based movement • endosomal transport • actin filament polymerization • regulation of T cell antigen processing and presentation • immune response • epidermis development • actin polymerization or depolymerization • T cell receptor signaling pathway • T cell activation • regulation of catalytic activity • Rho protein signal transduction • regulation of actin polymerization or depolymerization • regulation of lamellipodium assembly • Cdc42 protein signal transduction • regulation of stress fiber assembly • negative regulation of stress fiber assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7454	22376
Ensembl	ENSG00000015285	ENSMUSG00000031165
UniProt	P42768	P70315
RefSeq (mRNA)	NM_000377	NM_009515
RefSeq (protein)	NP_000368 NP_000368.1	NP_033541.1 NP_033541
Location (UCSC)	Chr X: 48.68 – 48.69 Mb	Chr X: 8.08 – 8.09 Mb
PubMed search

1CEE, 1EJ5, 1T84, 2A3Z, 2K42, 2OT0

7454

22376

ENSG00000015285

ENSMUSG00000031165

P42768

P70315

NM_000377

NM_009515

NP_000368
NP_000368.1

NP_033541.1
NP_033541

The Wiskott–Aldrich Syndrome protein (WASp) is a 502-amino acid protein expressed in cells of the hematopoietic system. In the inactive state, WASp exists in an autoinhibited conformation with sequences near its C-terminus binding to a region near its N-terminus. Its activation is dependent upon CDC42 and PIP2 acting to disrupt this interaction, causing the WASp protein to 'open'. This exposes a domain near the WASp C-terminus that binds to and activates the Arp2/3 complex. Activated Arp2/3 nucleates new F-actin.

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