"Who's That Girl" is a song by American singer Madonna from the soundtrack album to the 1987 film Who's That Girl. It was released on June 23, 1987, by Sire Records as the first album single. The song was later included on the two-disc edition of Madonna's 2009 greatest hits album Celebration. While shooting for the film, then called Slammer, Madonna had requested Patrick Leonard to develop an uptempo song that captured the nature of her film persona. She later added the lyrics and vocals to the demo tape developed by Leonard, and decided to rename the song as well as the film to "Who's That Girl".

Featuring instrumentation from drums, bass, and stringed instruments, "Who's That Girl" continued Madonna's fascination with Hispanic culture by incorporating Spanish lyrics and using the effect of double vocals. The song became Madonna's sixth single to top the Billboard Hot 100, while peaking atop the charts in countries like the United Kingdom, Canada, Netherlands, Ireland and Belgium. It was also nominated for "Best Song From A Motion Picture" at the 1988 Grammy Awards and "Best Original Song" at the 1988 Golden Globe Awards.

The music video portrayed a different persona of Madonna, rather than her film character for which it was released. Like the song, it incorporated Hispanic culture and portrayed her dressed in Spanish style as a young lady in search of a treasure. Madonna has performed the song on her Who's That Girl World Tour (1987) and on the Rebel Heart Tour (2015–2016). The song has been covered by many artists and has appeared in compilations and tribute albums.

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