"Who's Gonna Save My Soul" is the third and final single taken from hip-hop duo Gnarls Barkley's second studio album, The Odd Couple, released in late 2008. The song's official music video was directed by Chris Milk and was released on July 25, 2008. The video featured work by character animator Keith Sintay. The single was only released physically in America, in a special limited edition CD + DVD single package.

A couple sits at a booth in a diner, while the woman (Friday Night Lights star Aasha Davis) breaks up with her boyfriend (Saturday Night Live writer and The Lonely Island band member Jorma Taccone). After receiving the plate he requested from the waitress, the man stabs himself in the chest, and pulls out his heart, places it on the plate and gives it to the woman. He explains that his heart "is actually [hers] now," that he will never be able to get over her, and says "from now on every girl that I meet will be meticulously compared to the false memory of what you and I once 'had.'" The woman offers to return it after keeping it temporarily for a "shitty day" or when she needs to move something heavy, but the man insists that he is now "heartless" and thus will passively/aggressively ruin all his future relationships. The heart then comes to life, growing arms, legs and a mouth, and begins to sing the lyrics to the song on the counters of the diner using a piece of broccoli as a microphone before finally stabbing itself with a knife and pulling the man's head out of its body. The head looks around, staring off into space. The scene cuts back to the man staring out the window as the woman speaks. The woman finally asks, "Are you even listening to me?" The man simply replies "No." Cee-Lo and Danger Mouse also made cameos as chefs in the diner.

The song found popular acclaim: Entertainment Weekly put the video on its "Must List" and Rolling Stone on its "Hot List" in August 2008. On December 3, 2008, the video was nominated for the Grammy Award for Best Short Form Music Video. Sintay won a 2009 D&AD Yellow Pencil Award for Music Video Animation.

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