Walther Spielmeyer (23 April 1879 – 6 February 1935) was a German neuropathologist who was a native of Dessau.
He studied medicine at the University of Halle as a student of Eduard Hitzig (1838-1907). At Halle he was influenced by the work of psychiatrists Karl Heilbronner (1869-1914), Gustav Aschaffenburg (1866-1944) and pathologist Karl Joseph Eberth (1835-1926). In 1906 he relocated to Freiburg as an assistant to Alfred Hoche (1865-1943). At the suggestion of Emil Kraepelin (1856-1926), he succeeded Alois Alzheimer (1864-1915) as director of the Anatomisches Laboratorium der Psychiatrischen und Nervenklivik in Munich. At Munich he worked with Franz Nissl (1860-1919) and Felix Plaut (1877-1940).
In 1928 the Rockefeller Foundation financed the Kaiser Wilhelm Institute with Spielmeyer as director of the Hirnpathologisches Institut. He died of pulmonary tuberculosis on February 6, 1935.
Spielmeyer is remembered for his research of peripheral nervous system injuries as well as his specialized study of disturbed brain function caused by temporary circulation problems. He is credited with making significant contributions involving the function of glia in inflammatory processes and on the pathophysiology of cerebral blood flow in neurological-psychiatric disorders.