"Wagon Wheel" is a song co-written by Bob Dylan and Ketch Secor of Old Crow Medicine Show. Dylan recorded the chorus in 1973; Secor added verses 25 years later. Old Crow Medicine Show's final version was certified Platinum by the Recording Industry Association of America in April 2013. The song has been covered numerous times, most famously by Darius Rucker in 2013 — who made it into a No. 1 on the Hot Country Songs. English / Irish singer Nathan Carter covered the song in 2012.

The song describes a hitchhiking journey south along the eastern coast of the United States, from New England in the northeast, through Roanoke, Virginia with the intended destination of Raleigh, North Carolina, where the narrator hopes to see his lover. As the narrator is walking south of Roanoke, he catches a ride with a trucker who is traveling from Philadelphia through Virginia westward toward the Cumberland Gap and Johnson City, Tennessee. Secor's lyrics show a lack of knowledge of geography, however, as they state "he's a-heading west from the Cumberland Gap to Johnson City, Tennessee", whereas Johnson City is actually about 100 miles southeast of the Cumberland Gap. This mistake is also repeated in Darius Rucker's cover version of the song, but is corrected in Jason Lee Wilson's cover to "he's a heading west to the Cumberland Gap from Johnson City, Tennessee" on his 2010 "Big Gun" album.

Old Crow Medicine Show's version of the song is in 2/4 time signature, with an approximate tempo of 76 half notes per minute. It uses the I–V–vi–IV pattern in the key of A major, with the main chord pattern of A–E–F♯m–D.

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