Waddington Harbour is a harbour at the head of Bute Inlet in the Central Coast region of British Columbia, Canada. Also issuing into the head of Bute Inlet and Waddington Harbour, just west of the mouth of the Homathko, is the Teaquahan River. Issuing directly into the inlet a few miles south on the harbour's southeast is the Southgate River, one of the major rivers of the central Pacific Ranges, which begins on the west side of the Lillooet Icecap. Its lower valley adjacent to the inlet's shores is called Pigeon Valley.
Located immediately at the outlet of the Homathko River is Homathko Estuary Provincial Park, and Potato Point at 50°55′38″N 124°51′26″W / 50.92722°N 124.85722°W on the right (west) bank of the Homathko's mouth, which is the location of Potato Point Indian Reserve No. 3 and Hamilton Point slightly south along the Bute Inlet shoreline at 50°54′07″N 124°51′14″W / 50.90194°N 124.85389°W.Cumsack Creek flows from the east into the estuary just above the Homathko's mouth at 50°56′12″N 124°51′46″W / 50.93667°N 124.86278°W.