Live from Madison Square Garden, also called Live from MSG: Lesnar vs. Big Show, was a professional wrestling event produced by WWE. It took place on October 3, 2015 and aired exclusively on the WWE Network. The event was hailed as part one of Brock Lesnar's Go To Hell Tour and his return to Madison Square Garden in his first match in the arena since his original departure from the company in 2004. The event also marked the 25-year anniversary of Chris Jericho's debut in professional wrestling.

The show featured professional wrestling matches involving wrestlers from pre-existing scripted feuds or storylines that played out on WWE's primary television programs, Raw and SmackDown. Wrestlers portray heroes (faces) or villains (heels) as they follow a series of events that build tension and culminate in a wrestling match or series of matches.

The event featured Brock Lesnar in a match with Big Show, which was Lesnar's first match at Madison Square Garden since WrestleMania XX. Lesnar and Show previously had a feud in January 2014 after Show confronted Lesnar on the January 6 episode of Raw. There was a short physical confrontation between the two, starting a feud which was settled at the Royal Rumble 2014, where Show lost to Lesnar after being brutally assaulted with numerous steel chairs before the match began.

On the July 27 episode of Raw, United States Champion John Cena challenged WWE World Heavyweight Championship Seth Rollins but The Authority instead scheduled a match between the two for Cena's United States Championship. Cena won the match by submission, during which Rollins legit broke Cena's nose. Rollins then challenged Cena to a Title vs. Title match at SummerSlam, which Cena accepted. Rollins won the match when guest host Jon Stewart interfered on Rollins's behalf. At Night of Champions, Cena defeated Rollins to regain the United States Championship. The following night on Raw, Cena defeated Rollins in a rematch for the title.

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