Clash of Champions was a professional wrestling pay-per-view (PPV) event and WWE Network event produced by WWE. It took place on September 25, 2016 at the Bankers Life Fieldhouse in Indianapolis, Indiana. It was the first WWE event under the Clash of Champions chronology, replacing Night of Champions. It was the first Raw branded event following the second WWE brand extension in July 2016.

Eight matches were contested at the event, including one on the pre-show. The main event saw Kevin Owens defeat Seth Rollins to retain the WWE Universal Championship. Of the five Raw-exclusive championships, only the United States Championship changed hands, with Roman Reigns defeating the defending champion, Rusev.

The card included eight matches resulting from scripted storylines and have results predetermined by WWE on the Raw brand, one of WWE's brand divisions. Storylines are produced on WWE's weekly television show Monday Night Raw. Every championship exclusive to Raw – the Universal Championship, the United States Championship, the Cruiserweight Championship, and the brand's tag team and women's championships – were defended.