WNT3A

WNT3A
Identifiers
Aliases	WNT3A, Wnt family member 3A
External IDs	MGI: 98956 HomoloGene: 22528 GeneCards: WNT3A
Gene ontology Molecular function • protein domain specific binding • receptor binding • co-receptor binding • frizzled binding • frizzled-2 binding • protein binding • transcription coactivator activity • receptor agonist activity Cellular component • endocytic vesicle membrane • endoplasmic reticulum lumen • extracellular region • cell surface • extracellular exosome • Wnt-Frizzled-LRP5/6 complex • early endosome membrane • proteinaceous extracellular matrix • plasma membrane • Golgi lumen • presynapse • extracellular space Biological process • somitogenesis • cellular response to retinoic acid • hemopoiesis • positive regulation of protein phosphorylation • Wnt signaling pathway involved in forebrain neuroblast division • positive regulation of skeletal muscle tissue development • positive regulation of receptor internalization • axis elongation involved in somitogenesis • positive regulation of collateral sprouting in absence of injury • mammary gland development • platelet activation • heart looping • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein localization to plasma membrane • cardiac muscle cell fate commitment • mesoderm development • cell proliferation in forebrain • positive regulation of mesodermal cell fate specification • negative regulation of fat cell differentiation • canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • regulation of microtubule cytoskeleton organization • negative regulation of dopaminergic neuron differentiation • cell proliferation in midbrain • in utero embryonic development • negative regulation of axon extension involved in axon guidance • positive regulation of peptidyl-serine phosphorylation • positive regulation of transcription, DNA-templated • regulation of axonogenesis • positive regulation of B cell proliferation • post-anal tail morphogenesis • positive regulation of cardiac muscle cell differentiation • palate development • negative regulation of neuron projection development • paraxial mesodermal cell fate commitment • negative regulation of neurogenesis • positive regulation of protein tyrosine kinase activity • positive regulation of sequence-specific DNA binding transcription factor activity • extracellular matrix organization • positive regulation of neural precursor cell proliferation • synaptic vesicle recycling • osteoblast differentiation • skeletal muscle cell differentiation • canonical Wnt signaling pathway • COP9 signalosome assembly • dorsal/ventral neural tube patterning • positive regulation of protein binding • platelet aggregation • midbrain development • positive regulation of protein kinase activity • positive regulation of cell-cell adhesion mediated by cadherin • positive regulation of hepatocyte proliferation • neurogenesis • spinal cord association neuron differentiation • axonogenesis • positive regulation of cytokine production • positive regulation of dermatome development • positive regulation of catenin import into nucleus • somatic stem cell division • positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation • axon guidance • multicellular organism development • cellular protein localization • determination of left/right symmetry • inner ear morphogenesis • positive regulation of cell proliferation • regulation of cell differentiation • hippocampus development • negative regulation of heart induction by canonical Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter • anterior/posterior pattern specification • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation • beta-catenin destruction complex disassembly • neuron differentiation • Wnt signaling pathway • positive regulation of canonical Wnt signaling pathway • positive regulation of gene expression • calcium ion transmembrane transport via low voltage-gated calcium channel • presynapse assembly • negative regulation of neuron death • positive regulation of core promoter binding • regulation of RNA biosynthetic process • positive regulation of receptor activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	89780	22416
Ensembl	ENSG00000154342	ENSMUSG00000009900
UniProt	P56704	P27467
RefSeq (mRNA)	NM_033131	NM_009522
RefSeq (protein)	NP_149122	NP_033548.1 NP_033548
Location (UCSC)	Chr 1: 228.01 – 228.06 Mb	Chr 11: 59.25 – 59.29 Mb
PubMed search

89780

22416

ENSG00000154342

ENSMUSG00000009900

P56704

P27467

NM_033131

NM_009522

NP_149122

NP_033548.1
NP_033548

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis etc and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.

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