WNT3

WNT3
Identifiers
Aliases	WNT3, INT4, TETAMS, Wnt family member 3
External IDs	MGI: 98955 HomoloGene: 22527 GeneCards: WNT3
Genetically Related Diseases
Parkinson's disease
Gene ontology Molecular function • receptor agonist activity • protein domain specific binding • frizzled binding • protein binding • receptor binding Cellular component • cytoplasm • endocytic vesicle membrane • Wnt signalosome • endoplasmic reticulum lumen • proteinaceous extracellular matrix • plasma membrane • extracellular region • Golgi lumen • extracellular exosome • extracellular space Biological process • cellular response to retinoic acid • cell fate commitment • Spemann organizer formation at the anterior end of the primitive streak • head morphogenesis • limb bud formation • mammary gland epithelium development • anatomical structure formation involved in morphogenesis • mesoderm formation • positive regulation of collateral sprouting in absence of injury • negative regulation of axon extension involved in axon guidance • dorsal/ventral axis specification • axon guidance • limb development • multicellular organism development • positive regulation of Wnt signaling pathway • gamete generation • canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation • canonical Wnt signaling pathway involved in osteoblast differentiation • cell morphogenesis • canonical Wnt signaling pathway • anterior/posterior axis specification • embryonic forelimb morphogenesis • anterior/posterior pattern specification • embryonic hindlimb morphogenesis • Wnt signaling pathway • positive regulation of gene expression • regulation of neurogenesis • stem cell proliferation • canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation • canonical Wnt signaling pathway involved in stem cell proliferation • neuron differentiation • positive regulation of receptor activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7473	22415
Ensembl	n/a	ENSMUSG00000000125
UniProt	P56703	P17553
RefSeq (mRNA)	NM_030753	NM_009521
RefSeq (protein)	NP_110380	NP_033547.1 NP_033547
Location (UCSC)	Chr 17: 46.76 – 46.83 Mb	Chr 11: 103.77 – 103.82 Mb
PubMed search

7473

22415

n/a

ENSMUSG00000000125

P56703

P17553

NM_030753

NM_009521

NP_110380

NP_033547.1
NP_033547

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.

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Wikipedia