WHSC2

NELFA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5L3X
Identifiers
Aliases	NELFA, NELF-A, WHSC2, P/OKcl.15, negative elongation factor complex member A
External IDs	MGI: 1346098 HomoloGene: 68478 GeneCards: NELFA
Gene location (Human) Chr. Chromosome 4 (human) Band No data available Start 1,982,714 bp End 2,041,903 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band No data available Start 33,897,916 bp End 33,936,413 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • cytosol • nuclear body • NELF complex Biological process • multicellular organism development • transcription elongation from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of viral transcription • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7469	24116
Ensembl	ENSG00000185049	ENSMUSG00000029111
UniProt	Q9H3P2	Q8BG30
RefSeq (mRNA)	NM_005663	NM_011914
RefSeq (protein)	NP_005654	NP_036044
Location (UCSC)	Chr 4: 1.98 – 2.04 Mb	Chr 4: 33.9 – 33.94 Mb
PubMed search

5L3X

7469

24116

ENSG00000185049

ENSMUSG00000029111

Q9H3P2

Q8BG30

NM_005663

NM_011914

NP_005654

NP_036044

Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene.

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. WHSC2 encodes the NELF-A subunit of the NELF complex.

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Wikipedia