WAY-181,187

WAY-181,187
Clinical data

ATC code	none
Identifiers
IUPAC name 2-(1-{6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl}-1H-indol-3-yl)ethan-1-amine
CAS Number	554403-49-5
PubChem CID	10150497
IUPHAR/BPS	3240
ChemSpider	8326005
UNII	WXE3H7W295
ChEMBL	CHEMBL392760^Y
Chemical and physical data
Formula	C₁₅H₁₃ClN₄O₂S₂
Molar mass	380.872 g/mol
3D model (Jmol)	Interactive image
SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12
InChI InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2 Key:RYBOXBBYCVOYNO-UHFFFAOYSA-N

WAY-181,187 is a high affinity and selective 5-HT₆ receptor full agonist. It induces robust increases in extracellular GABA levels in the frontal cortex, hippocampus, striatum, and amygdala of rats without affecting concentrations in the nucleus accumbens or thalamus, and has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels in these areas. WAY-181,187 has demonstrated preclinical efficacy in rodent models of depression, anxiety, and notably obsessive-compulsive disorder, though it has also been shown to impair cognition and memory.