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Von Willebrand's disease

von Willebrand disease
Autosomal dominant - en.svg
von Willebrand disease types I and II are inherited in an autosomal dominant pattern.
Classification and external resources
Specialty Hematology
ICD-10 D68.0
ICD-9-CM 286.4
OMIM 193400
DiseasesDB 14007
MedlinePlus 000544
eMedicine ped/2419
MeSH D014842
GeneReviews
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Von Willebrand disease (vWD) (/ˌfʌnˈvɪlbrɑːnt/) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. It arises from a deficiency in the quality or quantity of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion. It is known to affect humans and several breeds of dogs. The three forms of vWD are: hereditary, acquired, and pseudo or platelet type. The three types of hereditary vWD are: vWD type 1, vWD type 2, and vWD type 3. Type 2 contains various subtypes. Platelet type vWD is also an inherited condition.

vWD type 2 is the most common type of the disorder.

vWD type 1 is the second most common type of the disorder which is typically asymptomatic, though mild symptoms such as nosebleeds may occur, and occasionally more severe symptoms. Blood type can affect the presentation and severity of symptoms of vWD.

vWD is named after Erik Adolf von Willebrand, a Finnish physician who first described the disease in 1926.

The various types of vWD present with varying degrees of bleeding tendency, usually in the form of easy bruising, nosebleeds, and bleeding gums. Women may experience heavy menstrual periods and blood loss during childbirth.


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