Vitronectin

VTN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OC0, 1S4G, 1SSU, 2JQ8, 3BT1, 3BT2, 4K24
Identifiers
Aliases	VTN, V75, VN, VNT, vitronectin
External IDs	OMIM: 193190 MGI: 98940 HomoloGene: 532 GeneCards: VTN
Gene ontology Molecular function • protein binding • scavenger receptor activity • heparin binding • extracellular matrix binding • polysaccharide binding • integrin binding • identical protein binding • collagen binding Cellular component • proteinaceous extracellular matrix • alphav-beta3 integrin-vitronectin complex • extracellular exosome • blood microparticle • extracellular region • Golgi lumen • basement membrane • rough endoplasmic reticulum lumen • cytoplasm • extracellular matrix • extracellular space • endoplasmic reticulum • intracellular membrane-bounded organelle Biological process • receptor-mediated endocytosis • positive regulation of protein binding • cell adhesion • positive regulation of cell-substrate adhesion • extracellular matrix organization • smooth muscle cell-matrix adhesion • regulation of complement activation • positive regulation of smooth muscle cell migration • negative regulation of endopeptidase activity • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of vascular endothelial growth factor receptor signaling pathway • immune response • endodermal cell differentiation • positive regulation of wound healing • positive regulation of receptor-mediated endocytosis • negative regulation of blood coagulation • oligodendrocyte differentiation • cell adhesion mediated by integrin • cell-matrix adhesion • protein polymerization • liver regeneration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7448	22370
Ensembl	ENSG00000109072	ENSMUSG00000017344
UniProt	P04004	P29788
RefSeq (mRNA)	NM_000638	NM_011707
RefSeq (protein)	NP_000629	NP_035837.1 NP_035837
Location (UCSC)	Chr 17: 28.37 – 28.37 Mb	Chr 11: 78.5 – 78.5 Mb
PubMed search

1OC0, 1S4G, 1SSU, 2JQ8, 3BT1, 3BT2, 4K24

7448

22370

ENSG00000109072

ENSMUSG00000017344

P04004

P29788

NM_000638

NM_011707

NP_000629

NP_035837.1
NP_035837

Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is abundantly found in serum, the extracellular matrix and bone. In humans it is encoded by the VTN gene.

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