Vincenzo Macchi (30 August 1770 – 30 September 1860) was an Italian Cardinal.
Born on 30 August 1770 in Capodimonte in the Papal States, he studied in Montefiascone and in Rome and was ordained a priest in 1794. In 1801 he gained his doctorate in utroque iure and was posted to the papal Nunciature in Lisbon, where he was active in the years 1801-1816, the years in which Wellington was organizing and leading the Peninsular Campaign. In 1818 he was appointed Archbishop of Nisibi in partibus and from late 1818 to October 1819 was in Lucerne as Nuncio to the Swiss Confederation. In the years 1819-1826 he was Nuncio in Paris, and was made Cardinal by Pope Leo XII in the consistory of 2 October 1826. In the years 1828-1830 he was Legate in Ravenna and Forlì and in 1836-1841 Legate in Bologna. Although considered a candidate in the Papal conclave of 1830-1, his backing was insufficient, despite the support of Giuseppe Albani. He never received more than twelve votes.
Subsequently, Macchi occupied various suburbicarian sees: as Cardinal Bishop of Palestrina in 1840, as Cardinal Bishop of Porto e Santa Rufina in 1844, and, as Dean of the College of Cardinals, was also Cardinal Bishop of Ostia from 1847. He likewise occupied in the last three decades of his life various posts in the Roman Curia.