Via Cristoforo Colombo (or just la Colombo, as it is often called by the Romans; Italian pronunciation: [kriˈstɔːforo koˈlombo]) is a street in Rome (Italy) that links the historic centre to Ostia. Along most of its route, the street has three lanes for each direction of movement. With its 27 kilometres (17 mi) length it is the longest Italian road among those included within the borders of a single municipality and, in several stretches, the largest in Italy.
Via Cristoforo Colombo starts from Porta Ardeatina and continues south-west, ending on the coast in the district of Castel Fusano.
The street was designed in 1937 with the name of Via Imperiale, as a part of the five-years plan of works associated to the 1941 World's fair of Rome: it should have linked the centre of the town to the new exhibition buildings (EUR) and then continue towards the Lido di Roma, according to Mussolini's project of enlargement of Rome to the sea.
It starts from the Aurelian Walls, close to Porta Ardeatina, and goes southward, soon trespassing a stretch of the bypass (Via Cilicia) and the rail circuit near the Roma Ostiense railway station.
At Piazza dei Navigatori it turns westward, running along the Palace of Lazio Region on the right and the former Fiera di Roma.
After passing the complex of junctions from which Viale Marconi starts (Marconi metro station, line B), it trespasses the sports facilities of Tre Fontane and enters the Europa Quarter.