Vascular endothelial growth factor D

VEGFD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XV7
Identifiers
Aliases	VEGFD, VEGF-D, FIGF, C-fos induced growth factor, c-fos induced growth factor (vascular endothelial growth factor D)
External IDs	MGI: 108037 HomoloGene: 3288 GeneCards: VEGFD
Gene ontology Molecular function • protein homodimerization activity • platelet-derived growth factor receptor binding • chemoattractant activity • protein binding • vascular endothelial growth factor receptor binding • growth factor activity • vascular endothelial growth factor receptor 3 binding Cellular component • membrane • extracellular region • platelet alpha granule lumen • extracellular space Biological process • dopaminergic neuron differentiation • cell differentiation • positive regulation of mast cell chemotaxis • platelet degranulation • induction of positive chemotaxis • multicellular organism development • positive regulation of cell proliferation • cell proliferation • positive regulation of cell division • positive chemotaxis • angiogenesis • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of angiogenesis • vascular endothelial growth factor receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2277	14205
Ensembl	ENSG00000165197	ENSMUSG00000031380
UniProt	O43915	P97946
RefSeq (mRNA)	NM_004469	NM_010216 NM_001308489
RefSeq (protein)	NP_004460	NP_001295418.1 NP_034346.1 NP_001295418 NP_034346
Location (UCSC)	Chr X: 15.35 – 15.38 Mb	Chr X: 164.37 – 164.4 Mb
PubMed search

2XV7

2277

14205

ENSG00000165197

ENSMUSG00000031380

O43915

P97946

NM_004469

NM_010216
NM_001308489

NP_004460

NP_001295418.1
NP_034346.1
NP_001295418
NP_034346

C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene.

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor C.

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