Vascular endothelial growth factor C

VEGFC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X1W, 2X1X, 4BSK
Identifiers
Aliases	VEGFC, Flt4-L, LMPH1D, VRP, vascular endothelial growth factor C
External IDs	MGI: 109124 HomoloGene: 3962 GeneCards: VEGFC
Gene ontology Molecular function • chemoattractant activity • protein binding • growth factor activity • vascular endothelial growth factor receptor 3 binding Cellular component • extracellular region • membrane • platelet alpha granule lumen • extracellular space Biological process • negative regulation of cell proliferation • positive regulation of neuroblast proliferation • positive regulation of protein secretion • substrate-dependent cell migration • signal transduction • positive regulation of protein autophosphorylation • multicellular organism development • morphogenesis of embryonic epithelium • positive regulation of cell-matrix adhesion • positive regulation of mast cell chemotaxis • positive regulation of blood vessel endothelial cell migration • positive regulation of cell division • induction of positive chemotaxis • platelet degranulation • positive regulation of peptidyl-tyrosine phosphorylation • negative regulation of blood pressure • positive regulation of cell proliferation • positive regulation of lymphangiogenesis • regulation of vascular endothelial growth factor receptor signaling pathway • response to drug • cell differentiation • positive regulation of epithelial cell proliferation • animal organ morphogenesis • positive chemotaxis • angiogenesis • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of angiogenesis • vascular endothelial growth factor receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7424	22341
Ensembl	ENSG00000150630	ENSMUSG00000031520
UniProt	P49767	P97953
RefSeq (mRNA)	NM_005429	NM_009506
RefSeq (protein)	NP_005420	NP_033532.1 NP_033532
Location (UCSC)	Chr 4: 176.68 – 176.79 Mb	Chr 8: 54.08 – 54.19 Mb
PubMed search

2X1W, 2X1X, 4BSK

7424

22341

ENSG00000150630

ENSMUSG00000031520

P49767

P97953

NM_005429

NM_009506

NP_005420

NP_033532.1
NP_033532

Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It is encoded in humans by the VEGFC gene, which is located on chromosome 4q34.

The main function of VEGF-C is in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration. It was discovered in 1996 as a ligand for the orphan receptor VEGFR-3. Soon thereafter, it was shown to be a specific growth factor for lymphatic vessels in a variety of models. However, in addition to its effect on lymphatic vessels, it can also promote the growth of blood vessels and regulate their permeability. The effect on blood vessels can be mediated via its primary receptor VEGFR-3 or its secondary receptor VEGFR-2. Apart from vascular targets, VEGF-C is also important for neural development and blood pressure regulation.

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Wikipedia