Vascular endothelial growth factor A

VEGFA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BJ1, 1CZ8, 1FLT, 1KAT, 1KMX, 1MJV, 1MKG, 1MKK, 1QTY, 1TZH, 1TZI, 1VGH, 1VPF, 1VPP, 2FJG, 2FJH, 2QR0, 2VGH, 2VPF, 3BDY, 3P9W, 3QTK, 3S1B, 3S1K, 3V2A, 4DEQ, 4GLN, 4GLS, 4KZN, 4QAF, 4WPB, 4ZFF, 5HHC, 5FV1, 5FV2, 5HHD, 5DN2
Identifiers
Aliases	VEGFA, MVCD1, VEGF, VPF, vascular endothelial growth factor A
External IDs	MGI: 103178 HomoloGene: 2534 GeneCards: VEGFA
Gene ontology Molecular function • heparin binding • extracellular matrix binding • cytokine activity • growth factor activity • neuropilin binding • vascular endothelial growth factor receptor 2 binding • receptor agonist activity • vascular endothelial growth factor receptor 1 binding • protein homodimerization activity • platelet-derived growth factor receptor binding • protein binding • vascular endothelial growth factor receptor binding • fibronectin binding • chemoattractant activity • identical protein binding • protein heterodimerization activity Cellular component • cytoplasm • membrane • extracellular region • cell surface • proteinaceous extracellular matrix • secretory granule • platelet alpha granule lumen • extracellular space Biological process • cardiac vascular smooth muscle cell development • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • vascular endothelial growth factor signaling pathway • positive regulation of receptor internalization • outflow tract morphogenesis • mammary gland alveolus development • positive regulation of tyrosine phosphorylation of Stat3 protein • monocyte differentiation • cell migration involved in sprouting angiogenesis • vasculogenesis • positive regulation of retinal ganglion cell axon guidance • vascular endothelial growth factor receptor signaling pathway • positive regulation of vascular permeability • positive regulation of mesenchymal cell proliferation • angiogenesis • positive regulation of blood vessel endothelial cell migration • positive regulation of ERK1 and ERK2 cascade • mesoderm development • positive regulation of positive chemotaxis • positive regulation of p38MAPK cascade • positive regulation of neuroblast proliferation • dopaminergic neuron differentiation • positive regulation of branching involved in ureteric bud morphogenesis • kidney development • lung development • coronary artery morphogenesis • in utero embryonic development • cell maturation • commissural neuron axon guidance • positive regulation of peptidyl-serine phosphorylation • growth • positive regulation of CREB transcription factor activity • basophil chemotaxis • artery morphogenesis • regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of peptidyl-tyrosine autophosphorylation • positive regulation of peptidyl-tyrosine phosphorylation • branching involved in blood vessel morphogenesis • positive regulation of protein localization to early endosome • primitive erythrocyte differentiation • positive regulation of protein kinase D signaling • lactation • cell differentiation • regulation of cGMP metabolic process • epithelial cell differentiation • positive regulation of leukocyte migration • positive regulation of epithelial cell proliferation • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • nervous system development • macrophage differentiation • positive regulation of angiogenesis • regulation of retinal ganglion cell axon guidance • lymph vessel morphogenesis • post-embryonic camera-type eye development • regulation of cell shape • ovarian follicle development • positive regulation of cellular component movement • branching morphogenesis of an epithelial tube • coronary vein morphogenesis • surfactant homeostasis • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to hypoxia • VEGF-activated neuropilin signaling pathway • positive regulation of endothelial cell proliferation • positive regulation of cell migration involved in sprouting angiogenesis • positive regulation of protein complex assembly • positive regulation of protein kinase C signaling • positive regulation of cell migration • heart morphogenesis • platelet degranulation • positive regulation of axon extension involved in axon guidance • cardiac muscle fiber development • positive regulation of endothelial cell migration • multicellular organism development • positive regulation of histone deacetylase activity • tube formation • positive regulation of gene expression • positive regulation of protein autophosphorylation • endothelial cell chemotaxis • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway • eye photoreceptor cell development • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of focal adhesion assembly • cellular response to vascular endothelial growth factor stimulus • activation of protein kinase activity • positive regulation of cell division • camera-type eye morphogenesis • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cell adhesion • cellular response to hypoxia • positive chemotaxis • regulation of transcription from RNA polymerase II promoter • positive regulation of cell proliferation • induction of positive chemotaxis • positive regulation of mast cell chemotaxis • motor neuron migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7422	22339
Ensembl	ENSG00000112715	ENSMUSG00000023951
UniProt	P15692	Q00731
RefSeq (mRNA)	NM_003376 NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_001204384 NM_001204385 NM_001287044 NM_001317010	NM_001025250 NM_001025257 NM_001110266 NM_001110267 NM_001110268 NM_001287056 NM_001287057 NM_001287058 NM_009505 NM_001317041
RefSeq (protein)	NP_001020537 NP_001020538 NP_001020539 NP_001020540 NP_001020541 NP_001028928 NP_001165093 NP_001165094 NP_001165095 NP_001165096 NP_001165097 NP_001165098 NP_001165099 NP_001165100 NP_001165101 NP_001191313 NP_001191314 NP_001273973 NP_001303939 NP_003367	NP_001020421.2 NP_001020428.2 NP_001103736.1 NP_001103737.1 NP_001103738.1 NP_001273985.1 NP_001273986.1 NP_001273987.1 NP_033531.3 NP_001303970.1 NP_001020421 NP_001020428 NP_001103736 NP_001103737 NP_001103738 NP_001273985 NP_001273986 NP_001273987 NP_001303970 NP_033531
Location (UCSC)	Chr 6: 43.77 – 43.79 Mb	Chr 17: 46.02 – 46.03 Mb
PubMed search

1BJ1, 1CZ8, 1FLT, 1KAT, 1KMX, 1MJV, 1MKG, 1MKK, 1QTY, 1TZH, 1TZI, 1VGH, 1VPF, 1VPP, 2FJG, 2FJH, 2QR0, 2VGH, 2VPF, 3BDY, 3P9W, 3QTK, 3S1B, 3S1K, 3V2A, 4DEQ, 4GLN, 4GLS, 4KZN, 4QAF, 4WPB, 4ZFF, 5HHC, 5FV1, 5FV2, 5HHD, 5DN2

...
Wikipedia