Valosin-containing protein

VCP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EBB, 3HU1, 3HU2, 3HU3, 3QC8, 3QQ7, 3QQ8, 3QWZ, 3TIW, 4KDI, 4KDL, 4KLN, 4KO8, 4KOD, 4P0A, 5C19, 3CF2, 3CF1, 5FTK, 5C18, 3CF3, 5FTJ, 5FTM, 5FTL, 5FTN, 5C1B, 5C1A, 5DYI, 5DYG
Identifiers
Aliases	VCP, ALS14, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97, Valosin-containing protein, CMT2Y, valosin containing protein
External IDs	MGI: 99919 HomoloGene: 5168 GeneCards: VCP
Gene ontology Molecular function • nucleotide binding • protein domain specific binding • protein complex binding • ADP binding • K48-linked polyubiquitin binding • BAT3 complex binding • polyubiquitin binding • protein binding • ubiquitin-like protein ligase binding • ubiquitin-specific protease binding • MHC class I protein binding • protein phosphatase binding • deubiquitinase activator activity • receptor binding • hydrolase activity • ATP binding • ubiquitin protein ligase binding • lipid binding • identical protein binding • ATPase activity • RNA binding Cellular component • site of double-strand break • cytosol • intracellular membrane-bounded organelle • endoplasmic reticulum membrane • myelin sheath • lipid particle • nucleoplasm • protein complex • VCP-NSFL1C complex • endoplasmic reticulum • Derlin-1 retrotranslocation complex • VCP-NPL4-UFD1 AAA ATPase complex • perinuclear region of cytoplasm • proteasome complex • nucleus • extracellular exosome • extracellular region • cytoplasm • secretory granule lumen • azurophil granule lumen • ficolin-1-rich granule lumen Biological process • regulation of aerobic respiration • regulation of apoptotic process • positive regulation of protein catabolic process • positive regulation of protein complex assembly • ubiquitin-dependent protein catabolic process • positive regulation of Lys63-specific deubiquitinase activity • establishment of protein localization • error-free translesion synthesis • viral genome replication • positive regulation of oxidative phosphorylation • ER-associated misfolded protein catabolic process • protein N-linked glycosylation via asparagine • cellular response to DNA damage stimulus • positive regulation of ATP biosynthetic process • endoplasmic reticulum unfolded protein response • ER to Golgi vesicle-mediated transport • ATP metabolic process • retrograde protein transport, ER to cytosol • NADH metabolic process • positive regulation of protein K63-linked deubiquitination • double-strand break repair • protein ubiquitination • ER-associated ubiquitin-dependent protein catabolic process • transport • positive regulation of mitochondrial membrane potential • activation of cysteine-type endopeptidase activity involved in apoptotic process • protein homooligomerization • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein hexamerization • aggresome assembly • flavin adenine dinucleotide catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • autophagy • DNA repair • ERAD pathway • positive regulation of ubiquitin-specific protease activity • autophagosome maturation • translesion synthesis • protein folding • protein methylation • protein deubiquitination • neutrophil degranulation • transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7415	269523
Ensembl	ENSG00000165280	ENSMUSG00000028452
UniProt	P55072	Q01853
RefSeq (mRNA)	NM_007126	NM_009503
RefSeq (protein)	NP_009057	NP_033529.3 NP_033529
Location (UCSC)	Chr 9: 35.06 – 35.07 Mb	Chr 4: 42.98 – 43 Mb
PubMed search

3EBB, 3HU1, 3HU2, 3HU3, 3QC8, 3QQ7, 3QQ8, 3QWZ, 3TIW, 4KDI, 4KDL, 4KLN, 4KO8, 4KOD, 4P0A, 5C19, 3CF2, 3CF1, 5FTK, 5C18, 3CF3, 5FTJ, 5FTM, 5FTL, 5FTN, 5C1B, 5C1A, 5DYI, 5DYG

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