The Vale of Pewsey or Pewsey Vale is an area of Wiltshire, England to the east of Devizes and south of Marlborough, centred on the town of Pewsey.
The vale is an extent of lower lying ground separating the chalk downs of Salisbury Plain to the south from the Marlborough Downs to the north. It is around 30 kilometres (19 mi) long and around 5 kilometres (3.1 mi) wide. At the western end is the town of Devizes. Larger settlements in the vale include Pewsey and Burbage with many smaller villages, the larger ones including Bishops Cannings, Etchilhampton, Urchfont, Chirton, Alton Priors, Woodborough, Milton Lilbourne, Easton Royal and Wootton Rivers.
Although not itself part of the downs, the vale is included as part of the North Wessex Downs AONB (Area of Outstanding Natural Beauty).
The vale is a major east-west feature opening to the west towards the Bristol Channel, but is drained by the headwaters of the Salisbury Avon, rather than the westward-flowing Bristol Avon. The river cuts through the chalk scarp to the south at Upavon and crosses Salisbury Plain towards the south coast. The higher part of the eastern vale south of Burbage is drained by the River Bourne, which cuts the scarp at Collingbourne Kingston, joining the Avon at Salisbury. Since the area is not believed to have been glaciated, this probably indicates that the course of the rivers pre-dates the modern topography.