VTCN1

VTCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GOS
Identifiers
Aliases	VTCN1, B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, V-set domain containing T cell activation inhibitor 1, V-set domain containing T-cell activation inhibitor 1
External IDs	MGI: 3039619 HomoloGene: 11627 GeneCards: VTCN1
Gene ontology Molecular function • receptor binding Cellular component • integral component of membrane • plasma membrane • membrane • external side of plasma membrane Biological process • interleukin-4 secretion • negative regulation of T cell activation • adaptive immune response • interferon-gamma secretion • positive regulation of T cell proliferation • response to protozoan • positive regulation of interleukin-2 secretion • immune system process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79679	242122
Ensembl	ENSG00000134258	ENSMUSG00000051076
UniProt	Q7Z7D3	Q7TSP5
RefSeq (mRNA)	NM_001253849 NM_001253850 NM_024626	NM_178594
RefSeq (protein)	NP_001240778 NP_001240779 NP_078902	NP_848709
Location (UCSC)	Chr 1: 117.14 – 117.21 Mb	Chr 3: 100.83 – 100.9 Mb
PubMed search

4GOS

79679

242122

ENSG00000134258

ENSMUSG00000051076

Q7Z7D3

Q7TSP5

NM_001253849
NM_001253850
NM_024626

NM_178594

NP_001240778
NP_001240779
NP_078902

NP_848709

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]

B7-H4 is an immune checkpoint molecule.

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