VPS35

VPS35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R17
Identifiers
Aliases	VPS35, MEM3, PARK17, VPS35 retromer complex component, retromer complex component
External IDs	MGI: 1890467 HomoloGene: 6221 GeneCards: VPS35
Gene ontology Molecular function • protein binding • D1 dopamine receptor binding • protein transporter activity Cellular component • cytoplasm • cytosol • endosome • membrane • tubular endosome • retromer complex • lysosomal membrane • early endosome • extracellular exosome • mitochondrion • lysosome • endosome membrane • postsynaptic density • retromer, cargo-selective complex • mitochondrion-derived vesicle • neuron projection • neuronal cell body • perinuclear region of cytoplasm • late endosome Biological process • regulation of protein stability • positive regulation of canonical Wnt signaling pathway • positive regulation of Wnt protein secretion • transcytosis • negative regulation of late endosome to lysosome transport • retrograde transport, endosome to Golgi • transport • protein transport • retrograde transport, endosome to plasma membrane • regulation of macroautophagy • Wnt signaling pathway • regulation of mitochondrion organization • regulation of cellular protein metabolic process • mitochondrial fragmentation involved in apoptotic process • positive regulation of dopamine receptor signaling pathway • positive regulation of mitochondrial fission • mitochondrion to lysosome transport • neurotransmitter receptor transport, endosome to plasma membrane • regulation of dendritic spine maintenance • positive regulation of cellular protein catabolic process • regulation of terminal button organization • lysosome organization • positive regulation of gene expression • negative regulation of gene expression • protein destabilization • negative regulation of protein homooligomerization • protein localization to organelle • voluntary musculoskeletal movement • positive regulation of locomotion involved in locomotory behavior • negative regulation of neuron death • positive regulation of dopamine biosynthetic process • negative regulation of cellular protein localization • negative regulation of lysosomal protein catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55737	65114
Ensembl	ENSG00000069329	ENSMUSG00000031696
UniProt	Q96QK1	Q9EQH3
RefSeq (mRNA)	NM_018206	NM_022997
RefSeq (protein)	NP_060676	NP_075373.1 NP_075373
Location (UCSC)	Chr 16: 46.66 – 46.69 Mb	Chr 8: 85.26 – 85.3 Mb
PubMed search

2R17

55737

65114

ENSG00000069329

ENSMUSG00000031696

Q96QK1

Q9EQH3

NM_018206

NM_022997

NP_060676

NP_075373.1
NP_075373

Vacuolar protein sorting-associated protein 35 is a protein that in humans is encoded by the VPS35 gene.

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.

Vps35 is the largest subunit of retromer with the molecular weight of 92-kDa and functions as the central platform for the assembly of Vps26 and Vps29. Vps35 resembles many other helical solenoid proteins including AP adaptor protein complexes that are characterized with repeated structural units in a continuous superhelix arrangement involved in coated vesicle trafficking. The curved surface of the 6 even-numbered helices within solenoid structure with series of ridges separating hydrophobic grooves function as potential cargo binding sites. The C-terminal of Vps35 contains an α-solenoid fold that fits into the metal binding pocket of Vps29.

...
Wikipedia