VHL

VHL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WQO, 1LM8, 1LQB, 1VCB, 3ZRC, 3ZRF, 3ZTC, 3ZTD, 3ZUN, 4AJY, 4AWJ, 4B95, 4B9K, 4BKS, 4BKT, 4W9C, 4W9D, 4W9E, 4W9F, 4W9G, 4W9H, 4W9I, 4W9J, 4W9K, 4W9L
Identifiers
Aliases	VHL, HRCA1, RCA1, VHL1, pvon Hippel-Lindau tumor suppressor
External IDs	OMIM: 608537 MGI: 103223 HomoloGene: 465 GeneCards: VHL
Gene ontology Molecular function • ubiquitin protein ligase activity • transcription factor binding • ubiquitin-protein transferase activity • protein binding • enzyme binding Cellular component • cytoplasm • cytosol • VCB complex • membrane • nucleoplasm • endoplasmic reticulum • mitochondrion • nucleus Biological process • regulation of transcription, DNA-templated • protein stabilization • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • proteolysis • positive regulation of transcription, DNA-templated • protein ubiquitination • positive regulation of cell differentiation • cell morphogenesis • regulation of transcription from RNA polymerase II promoter in response to hypoxia • negative regulation of transcription from RNA polymerase II promoter in response to hypoxia • negative regulation of cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7428	22346
Ensembl	ENSG00000134086	ENSMUSG00000033933
UniProt	P40337	P40338
RefSeq (mRNA)	NM_000551 NM_198156	NM_009507
RefSeq (protein)	NP_000542 NP_937799 NP_000542.1	NP_033533.1 NP_033533
Location (UCSC)	Chr 3: 10.14 – 10.15 Mb	Chr 6: 113.62 – 113.63 Mb
PubMed search

4WQO, 1LM8, 1LQB, 1VCB, 3ZRC, 3ZRF, 3ZTC, 3ZTD, 3ZUN, 4AJY, 4AWJ, 4B95, 4B9K, 4BKS, 4BKT, 4W9C, 4W9D, 4W9E, 4W9F, 4W9G, 4W9H, 4W9I, 4W9J, 4W9K, 4W9L

7428

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Wikipedia