VAV1

VAV1

Protein VAV1 PDB 1k1z.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9

Identifiers

VAV1, VAV, vav guanine nucleotide exchange factor 1

External IDs

MGI: 98923 HomoloGene: 3961 GeneCards: VAV1

Gene ontology
Molecular function	• Rac guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • transcription factor activity, sequence-specific DNA binding • metal ion binding • protein binding • Rho guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • phosphotyrosine binding
Cellular component	• cytosol • cell-cell junction • plasma membrane
Biological process	• regulation of cell size • G-protein coupled receptor signaling pathway • intracellular signal transduction • Fc-gamma receptor signaling pathway involved in phagocytosis • regulation of GTPase activity • T cell costimulation • neutrophil chemotaxis • reactive oxygen species metabolic process • platelet activation • Fc-epsilon receptor signaling pathway • positive regulation of GTPase activity • T cell differentiation • vascular endothelial growth factor receptor signaling pathway • immune response • phagocytosis • positive regulation of apoptotic process • integrin-mediated signaling pathway • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of natural killer cell mediated cytotoxicity • T cell activation • phosphatidylinositol-mediated signaling • positive regulation of cell adhesion • regulation of transcription, DNA-templated • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol phosphorylation • small GTPase mediated signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE VAV1 206219 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


7409


22324


ENSG00000141968


ENSMUSG00000034116


P15498


P27870

RefSeq (mRNA)


NM_001258206 NM_001258207 NM_005428


NM_001163815 NM_001163816 NM_011691

RefSeq (protein)


NP_001245135 NP_001245136 NP_005419


NP_035821.3 NP_001157287 NP_001157288 NP_035821

Location (UCSC)

Chr 19: 6.77 – 6.86 Mb

Chr 17: 57.28 – 57.33 Mb

PubMed search

2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9

ENSG00000141968

ENSMUSG00000034116

NM_001258206
NM_001258207
NM_005428

NM_001163815
NM_001163816
NM_011691

NP_001245135
NP_001245136
NP_005419

NP_035821.3
NP_001157287
NP_001157288
NP_035821

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Wikipedia

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