VAPB

VAPB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MDK, 3IKK
Identifiers
Aliases	VAPB, ALS8, VAMP-B, VAP-B, VAMP (vesicle-associated membrane protein)-associated protein B and C, VAMP associated protein B and C
External IDs	MGI: 1928744 HomoloGene: 36163 GeneCards: VAPB
Gene ontology Molecular function • protein homodimerization activity • microtubule binding • protein binding • beta-tubulin binding • protein heterodimerization activity • FFAT motif binding • enzyme binding • cadherin binding involved in cell-cell adhesion Cellular component • integral component of membrane • Golgi apparatus • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • endoplasmic reticulum exit site • cell-cell adherens junction • Golgi membrane • cytoplasm Biological process • activation of signaling protein activity involved in unfolded protein response • positive regulation by host of viral release from host cell • COPII-coated vesicle budding • cellular calcium ion homeostasis • sphingolipid biosynthetic process • endoplasmic reticulum organization • positive regulation by host of viral genome replication • endoplasmic reticulum unfolded protein response • ER to Golgi vesicle-mediated transport • response to unfolded protein • negative regulation by host of viral release from host cell • modulation by virus of host morphology or physiology • negative regulation by host of viral genome replication • positive regulation of viral genome replication • negative regulation by virus of viral protein levels in host cell • viral process • cell-cell adhesion • modulation by host of viral RNA genome replication Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9217	56491
Ensembl	ENSG00000124164	ENSMUSG00000054455
UniProt	O95292	Q9QY76
RefSeq (mRNA)	NM_001195677 NM_004738	NM_019806
RefSeq (protein)	NP_001182606 NP_004729	n/a
Location (UCSC)	Chr 20: 58.39 – 58.45 Mb	Chr 2: 173.74 – 173.78 Mb
PubMed search

2MDK, 3IKK

9217

56491

ENSG00000124164

ENSMUSG00000054455

O95292

Q9QY76

NM_001195677
NM_004738

NM_019806

NP_001182606
NP_004729

n/a

Vesicle-associated membrane protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene. The VAPB gene is found on the 20th human chromosome.

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.

Like VAPA, VAPB binds to proteins that contain a FFAT motif. Considerable interest in VAPB has arisen because mutations in this protein are associated with rare, familial forms of Motor Neurone Disease (also called Amyotrophic Lateral Sclerosis and Lou Gehrig's disease).

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