V-myc

MYCN
Identifiers
Aliases	MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor
External IDs	OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN
Gene ontology Molecular function • DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • protein binding Cellular component • chromatin • nucleus • nucleolus Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • GO:0006350 transcription, DNA-templated • positive regulation of gene expression • negative regulation of gene expression • positive regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4613	18109
Ensembl	ENSG00000134323	ENSMUSG00000037169
UniProt	P04198	P03966
RefSeq (mRNA)	NM_005378 NM_001293228 NM_001293231 NM_001293233	NM_008709
RefSeq (protein)	NP_001280157 NP_001280160 NP_001280162 NP_005369	NP_032735.3 NP_032735
Location (UCSC)	Chr 2: 15.94 – 15.95 Mb	Chr 12: 12.94 – 12.94 Mb
PubMed search

4613

18109

ENSG00000134323

ENSMUSG00000037169

P04198

P03966

NM_005378
NM_001293228
NM_001293231
NM_001293233

NM_008709

NP_001280157
NP_001280160
NP_001280162
NP_005369

NP_032735.3
NP_032735

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

The MYCN gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. N-Myc is highly expressed in the fetal brain and is critical for normal brain development.

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Wikipedia