Utomilumab

TNFRSF9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D0J
Identifiers
Aliases	TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9
External IDs	OMIM: 602250 MGI: 1101059 HomoloGene: 1199 GeneCards: TNFRSF9
Gene ontology Molecular function • cytokine binding • tumor necrosis factor-activated receptor activity • receptor activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane • external side of plasma membrane • extracellular space • plasma membrane Biological process • multicellular organism development • regulation of apoptotic process • negative regulation of interleukin-12 secretion • response to lipopolysaccharide • negative regulation of interleukin-10 secretion • inflammatory response • immune response • protein homotrimerization • apoptotic process • negative regulation of cell proliferation • tumor necrosis factor-mediated signaling pathway • regulation of cell proliferation • apoptotic signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3604	21942
Ensembl	ENSG00000049249	ENSMUSG00000028965
UniProt	Q07011	P20334
RefSeq (mRNA)	NM_001561	NM_001077508 NM_001077509 NM_011612
RefSeq (protein)	NP_001552	NP_001070977.1 NP_035742.1 NP_001070976 NP_001070977 NP_035742
Location (UCSC)	Chr 1: 7.92 – 7.94 Mb	Chr 4: 150.91 – 150.95 Mb
PubMed search

1D0J

3604

21942

ENSG00000049249

ENSMUSG00000028965

Q07011

P20334

NM_001561

NM_001077508
NM_001077509
NM_011612

NP_001552

NP_001070977.1
NP_035742.1
NP_001070976
NP_001070977
NP_035742

CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.

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Wikipedia