Urotensin-II

UTS2
Identifiers
Aliases	UTS2, PRO1068, U-II, UCN2, UII, urotensin 2
External IDs	MGI: 1346329 HomoloGene: 4939 GeneCards: UTS2
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.23 Start 7,843,083 bp End 7,853,512 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 E2 Start 150,997,097 bp End 151,001,810 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • hormone activity • receptor binding Cellular component • extracellular region • cell • extracellular space Biological process • positive regulation of collagen biosynthetic process • negative regulation of insulin secretion • muscle contraction • response to hypoxia • negative regulation of urine volume • negative regulation of blood pressure • response to testosterone • positive regulation of fibroblast proliferation • positive regulation of cytosolic calcium ion concentration • positive regulation of synaptic transmission, cholinergic • negative regulation of heart rate • positive regulation of angiogenesis • positive regulation of heart rate • regulation of blood pressure • positive regulation of blood pressure • positive regulation of circadian sleep/wake cycle, REM sleep • positive regulation of cell differentiation • positive regulation of circadian sleep/wake cycle, wakefulness • negative regulation of renal sodium excretion • negative regulation of glomerular filtration • positive regulation of fibroblast migration • response to drug • chemical synaptic transmission • regulation of blood vessel diameter • positive regulation of blood vessel diameter • regulation of receptor activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10911	24111
Ensembl	ENSG00000049247	ENSMUSG00000028963
UniProt	O95399	Q9QZQ3
RefSeq (mRNA)	NM_006786 NM_021995	NM_011910
RefSeq (protein)	NP_006777 NP_068835	NP_036040
Location (UCSC)	Chr 1: 7.84 – 7.85 Mb	Chr 1: 151 – 151 Mb
PubMed search

Urotensin-II

Names
IUPAC name L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine (5→10)-disulfide
Identifiers
3D model (JSmol)	Interactive image
ChemSpider	24646295
InChI InChI=1S/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1 Key: HFNHAPQMXICKCF-USJMABIRSA-N InChI=1/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1 Key: HFNHAPQMXICKCF-USJMABIRBM
SMILES C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)Cc3ccccc3)Cc4c[nH]c5c4cccc5)CCCCN)Cc6ccc(cc6)O)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](CCC(=O)O)N)O
Properties
Chemical formula	C64H85N13O18S2
Molar mass	1388.6 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

10911

24111

ENSG00000049247

ENSMUSG00000028963

O95399

Q9QZQ3

NM_006786
NM_021995

NM_011910

NP_006777
NP_068835

NP_036040

Urotensin-II (U-II) is a peptide ligand that is the strongest known vasoconstrictor. Because of the involvement of the UII system in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal, it represents a promising target for the development of new drugs.

In humans, Urotensin-2 is encoded by the UTS2 gene.

U-II was initially isolated from the neurosecretory system of the Goby fish (Gillichthys mirabilis). For many years it was thought that U-II does not exhibit significant effects in mammalian systems; a view quickly overturned when it was demonstrated that Goby U-II produces slow relaxation of mouse anococcygeus muscle, in addition to contraction of rat artery segments. In 1998, the genes for Pre-pro U-II were found in mammals proving that the peptide U-II did exist in mammals.