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The 2016 United States Senate election in Missouri was held on November 8, 2016, to elect a member of the United States Senate to represent the State of Missouri, concurrently with the 2016 U.S. presidential election, as well as other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections. The primaries were held on August 2.
Incumbent Republican Senator Roy Blunt won re-election to a second term in office.
Despite being considered an “establishment” Republican, Blunt is considered to be unlikely to face serious Tea Party opposition because of Blunt's efforts to cultivate relationships with activists in Missouri, his effectiveness at "thread[ing] the needle" by keeping conservative and establishment Republicans fairly satisfied, and the open gubernatorial election, which is attracting the most attention from Republicans.