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The 2012 United States Senate election in Mississippi was held on November 6, 2012, alongside the 2012 U.S. presidential election, other elections to the United States Senate in other states, as well as elections to the United States House of Representatives and various state and local elections. Incumbent Republican U.S. Senator Roger Wicker won re-election to his first full term, while Albert N. Gore (distantly related to former U.S. Vice-President Al Gore) was the Democratic nominee.
Former U.S. representative Roger Wicker was appointed by Governor Haley Barbour after then-incumbent Trent Lott retired at the end of 2007. A 2008 special election was later scheduled to determine who would serve the remainder of the term. Then-U.S. Sen. Roger Wicker defeated former Mississippi Governor Ronnie Musgrove with 54.96% of the vote in the special election and will be up for re-election in 2012.