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The 2010 United States Senate election in Arizona took place on November 2, 2010 along with other elections to the United States Senate in other states as well as elections to the United States House of Representatives and various state and local elections. The primaries were held on August 24, 2010. Incumbent Republican U.S. Senator John McCain won reelection to a fifth term.
Many considered popular Democratic Governor Janet Napolitano a possible Democratic challenger to McCain, and some very early polling showed her ahead or competitive with him in a prospective 2010 matchup. Napolitano was term-limited as governor in 2010, and had openly discussed the possibility of a Senate race, especially given McCain's 2008 electoral results in the Democratic-trending state.
However, the December 1, 2008 nomination by President-elect Barack Obama of Napolitano to be the new Secretary of Homeland Security, made it appear unlikely that she would challenge McCain.