USS Genesee (1862) was a steamer acquired by the Union Navy during the American Civil War. She was used by the Navy to patrol navigable waterways of the Confederacy to prevent the South from trading with other countries.
Genesee was launched 2 April 1862 by the Boston Navy Yard; sponsored by Miss Emily Dorr; and commissioned 3 July 1862, Comdr. William M. Macomb in command.
Assigned to the North Atlantic Blockading Squadron, Genesee sailed from Boston, Massachusetts, 6 July 1862 for Hampton Roads, Virginia, where she convoyed U.S. mail steamers in the James River until departing 19 October for blockade duty off North Carolina. For over 3 months she helped seal Wilmington, North Carolina, and Beaufort from Confederate blockade runners.
She got underway 19 February 1863 to join the West Gulf Blockading Squadron, arriving New Orleans, Louisiana, 7 March in time to join Rear Admiral David Farragut's expedition up the Mississippi River past Port Hudson, Louisiana, to cut off Confederate supplies from the Red River and to join Admiral David Dixon Porter and General U.S. Grant in operations against Vicksburg, Mississippi.