UQCRFS1

UQCRFS1
Identifiers
Aliases	UQCRFS1, RIP1, RIS1, RISP, UQCR5, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
External IDs	MGI: 1913944 HomoloGene: 4378 GeneCards: UQCRFS1
Gene ontology Molecular function • ubiquinol-cytochrome-c reductase activity • protein complex binding • iron-sulfur cluster binding • metal ion binding • oxidoreductase activity • 2 iron, 2 sulfur cluster binding • oxidoreductase activity, acting on diphenols and related substances as donors • protein binding Cellular component • integral component of membrane • membrane • mitochondrial membrane • myelin sheath • mitochondrion • mitochondrial inner membrane • respiratory chain • mitochondrial respiratory chain complex III • mitochondrial respiratory chain complex IV Biological process • hydrogen ion transmembrane transport • response to antibiotic • response to hormone • oxidation-reduction process • response to drug • mitochondrial electron transport, ubiquinol to cytochrome c Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7386	66694
Ensembl	ENSG00000169021	ENSMUSG00000038462
UniProt	P47985	Q9CR68
RefSeq (mRNA)	NM_006003	NM_025710
RefSeq (protein)	NP_005994	NP_079986
Location (UCSC)	Chr 19: 29.21 – 29.21 Mb	Chr 13: 30.54 – 30.55 Mb
PubMed search

7386

66694

ENSG00000169021

ENSMUSG00000038462

P47985

Q9CR68

NM_006003

NM_025710

NP_005994

NP_079986

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, is a protein which in humans is encoded by the UQCRFS1 gene.

UQCRFS1 is a subunit of the respiratory chain protein (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene:

and ten nuclear genes:

After processing the cleaved leader sequence of the iron-sulfur protein is retained as subunit 9, giving 11 subunits from 10 genes.

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