UPF2

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1UW4, 2WJV, 4CEK, 4CEM

Identifiers

Aliases

UPF2, HRENT2, smg-3, UPF2 regulator of nonsense transcripts homolog (yeast)

External IDs

MGI: 2449307 HomoloGene: 6101 GeneCards: UPF2

Genetically Related Diseases

prostate cancer

Gene ontology
Molecular function	• protein binding • telomeric DNA binding • RNA binding
Cellular component	• cytoplasm • perinuclear region of cytoplasm • exon-exon junction complex • nucleus • P-body • cytosol • polysome
Biological process	• liver development • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • mRNA export from nucleus • animal organ regeneration
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


26019


326622

Ensembl


ENSG00000151461


ENSMUSG00000043241

UniProt


Q9HAU5


n/a

RefSeq (mRNA)


NM_015542 NM_080599


NM_001081132

RefSeq (protein)


NP_056357 NP_542166


n/a

Location (UCSC)

Chr 10: 11.92 – 12.04 Mb

Chr 2: 5.95 – 6.06 Mb

PubMed search

1UW4, 2WJV, 4CEK, 4CEM

n/a

n/a

Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene.

This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.

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