UGT1A4

UGT1A4
Identifiers
Aliases	UGT1A4, HUG-BR2, UDPGT, UDPGT 1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D, UGT1A4S, UDP glucuronosyltransferase family 1 member A4
External IDs	MGI: 3032634 HomoloGene: 88621 GeneCards: UGT1A4
Gene ontology Molecular function • transferase activity • retinoic acid binding • transferase activity, transferring hexosyl groups • protein homodimerization activity • transferase activity, transferring glycosyl groups • protein heterodimerization activity • enzyme binding • glucuronosyltransferase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum Biological process • negative regulation of cellular glucuronidation • heme catabolic process • cellular glucuronidation • xenobiotic glucuronidation • drug metabolic process • metabolic process • negative regulation of glucuronosyltransferase activity • negative regulation of fatty acid metabolic process • bilirubin conjugation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54657	394433
Ensembl	ENSG00000244474	ENSMUSG00000089943
UniProt	P22310	n/a
RefSeq (mRNA)	NM_007120	NM_201643
RefSeq (protein)	NP_009051	n/a
Location (UCSC)	Chr 2: 233.72 – 233.77 Mb	Chr 1: 88.17 – 88.22 Mb
PubMed search

54657

394433

ENSG00000244474

ENSMUSG00000089943

P22310

n/a

NM_007120

NM_201643

NP_009051

n/a

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although it is more active on amines, steroids, and sapogenins. It is the main enzyme responsible for glucuronidation of the anticonvulsant lamotrigine.

...
Wikipedia