UGT1A1

UGT1A1
Identifiers
Aliases	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A, UDP glucuronosyltransferase family 1 member A1
External IDs	OMIM: 191740 MGI: 98898 HomoloGene: 128034 GeneCards: UGT1A1
Gene ontology Molecular function • transferase activity • enzyme inhibitor activity • retinoic acid binding • transferase activity, transferring hexosyl groups • protein homodimerization activity • transferase activity, transferring glycosyl groups • steroid binding • protein heterodimerization activity • enzyme binding • glucuronosyltransferase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • integral component of plasma membrane • cytochrome complex • endoplasmic reticulum chaperone complex • endoplasmic reticulum Biological process • steroid metabolic process • response to organic cyclic compound • cellular response to ethanol • estrogen metabolic process • response to nutrient • negative regulation of steroid metabolic process • bilirubin conjugation • digestion • response to steroid hormone • response to glucocorticoid • retinoic acid metabolic process • negative regulation of cellular glucuronidation • response to organic substance • response to lipopolysaccharide • cellular response to hormone stimulus • heme catabolic process • cellular response to glucocorticoid stimulus • acute-phase response • heterocycle metabolic process • animal organ regeneration • drug metabolic process • response to starvation • flavone metabolic process • liver development • metabolic process • negative regulation of glucuronosyltransferase activity • response to ethanol • negative regulation of fatty acid metabolic process • response to drug • biphenyl catabolic process • cellular response to estradiol stimulus • flavonoid glucuronidation • cellular glucuronidation • xenobiotic glucuronidation • cellular response to xenobiotic stimulus • negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54658	394436
Ensembl	ENSG00000241635	ENSMUSG00000089960
UniProt	P22309	Q63886
RefSeq (mRNA)	NM_000463	NM_201645
RefSeq (protein)	NP_000454	NP_964007.2 NP_964007
Location (UCSC)	Chr 2: 233.76 – 233.77 Mb	Chr 1: 88.21 – 88.22 Mb
PubMed search

54658

394436

ENSG00000241635

ENSMUSG00000089960

P22309

Q63886

NM_000463

NM_201645

NP_000454

NP_964007.2
NP_964007

UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.

UGT-1A is a uridine diphosphate glucuronosyltransferase (UDP-glucuronosyltransferase, UDPGT), an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.

The UGT1A1 gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Over 100 genetic variants within the UGT1A1 gene have been described, some of which confer increased, reduced or inactive enzymatic activity. The UGT nomenclature committee has compiled a list of these variants, naming each with a * symbol followed by a number.

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Wikipedia