UCHL1

UCHL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JKJ, 2ETL, 2LEN, 3IFW, 3IRT, 3KVF, 3KW5, 4DM9
Identifiers
Aliases	UCHL1, HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1, HEL-S-53, ubiquitin C-terminal hydrolase L1
External IDs	OMIM: 191342 MGI: 103149 HomoloGene: 37894 GeneCards: UCHL1
Gene ontology Molecular function • cysteine-type peptidase activity • peptidase activity • ligase activity • ubiquitin binding • protein binding • alpha-2A adrenergic receptor binding • thiol-dependent ubiquitin-specific protease activity • omega peptidase activity • cysteine-type endopeptidase activity • hydrolase activity • ubiquitin protein ligase binding • thiol-dependent ubiquitinyl hydrolase activity Cellular component • cytoplasm • membrane • endoplasmic reticulum membrane • myelin sheath • plasma membrane • intracellular • nucleoplasm • axon • neuronal cell body • endoplasmic reticulum • neuron projection terminus • extracellular exosome • axon cytoplasm • cytosol Biological process • axon target recognition • eating behavior • axonogenesis • ubiquitin-dependent protein catabolic process • proteolysis • axonal transport of mitochondrion • response to ischemia • neuromuscular process • muscle fiber development • negative regulation of MAP kinase activity • sensory perception of pain • cell proliferation • regulation of macroautophagy • adult walking behavior • proteasome-mediated ubiquitin-dependent protein catabolic process • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7345	22223
Ensembl	ENSG00000154277	ENSMUSG00000029223
UniProt	P09936	Q9R0P9
RefSeq (mRNA)	NM_004181	NM_011670
RefSeq (protein)	NP_004172	NP_035800.2 NP_035800
Location (UCSC)	Chr 4: 41.26 – 41.27 Mb	Chr 5: 66.68 – 66.69 Mb
PubMed search

4JKJ, 2ETL, 2LEN, 3IFW, 3IRT, 3KVF, 3KW5, 4DM9

7345

22223

ENSG00000154277

ENSMUSG00000029223

P09936

Q9R0P9

NM_004181

NM_011670

NP_004172

NP_035800.2
NP_035800

Ubiquitin carboxy-terminal hydrolase L1 (EC 3.1.2.15, ubiquitin C-terminal hydrolase, UCH-L1) is a deubiquitinating enzyme.

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