U2 small nuclear RNA auxiliary factor 1

U2AF1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1JMT
Identifiers
Aliases	U2AF1, FP793, RN, RNU2AF35, U2AFBP, U2 small nuclear RNA auxiliary factor 1
External IDs	HomoloGene: 134334 GeneCards: U2AF1
Gene ontology Molecular function • metal ion binding • protein binding • nucleic acid binding • pre-mRNA 3'-splice site binding • RNA binding Cellular component • Cajal body • nuclear speck • catalytic step 2 spliceosome • U2AF • nucleoplasm • spliceosomal complex • nucleus Biological process • termination of RNA polymerase II transcription • positive regulation of protein targeting to mitochondrion • mRNA processing • mRNA export from nucleus • regulation of autophagy of mitochondrion • RNA splicing • mRNA 3'-end processing • RNA export from nucleus • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7307	n/a
Ensembl	n/a	n/a
UniProt	Q01081 P0DN76	n/a
RefSeq (mRNA)	NM_001025203 NM_001025204 NM_006758	n/a
RefSeq (protein)	NP_001020374.1 NP_001020375.1 NP_006749.1 NP_001307575.1 NP_001307577.1 NP_001307580.1 NP_006749.1 NP_001307575.1	n/a
Location (UCSC)	n/a	n/a
PubMed search		n/a

1JMT

7307

n/a

n/a

n/a

Q01081
P0DN76

n/a

NM_001025203
NM_001025204
NM_006758

n/a

NP_001307580.1
NP_006749.1
NP_001307575.1

n/a

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.

U2 small nuclear RNA auxiliary factor 1 has been shown to interact with:

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