U.S. Route 49B (Brookland, Arkansas)

U.S. Route 49
Highway system
United States Numbered Highway System List Special Divided Replaced

U.S. Route 49 Business
Location	Hattiesburg, Mississippi

U.S. Route 49E Business
Location	Greenwood, Mississippi

Several special routes of U.S. Route 49 exist. In order from south to north they are as follows.

U.S. Highway 49 Business (US 49B, Hwy. 49B) is a 6.92-mile (11.14 km) business route of U.S. Route 49 in Phillips County.

The route's northern terminus is at US 49 in Helena-West Helena. It runs south as Sebastian Street and splits into two divided one-way streets known as Plaza Avenue at a junction Highway 242. These routes overlap for 0.13 miles (0.21 km) until Highway 242 turns north along 4th Street, where a concurrency with Crowley's Ridge Parkway (CRP). The one-way streets merge and become Richmond Drive headed east. US 49B passes the Faust House, Myers House, Central High School and the Helena Country Club before meeting the former corporate limit of West Helena prior to their 2005 merger. The route winds and splits into two divided one-way streets begin as it enters the area formerly designated as Helena. After a junction with Highway 185 the routes pass several historical properties on the National Register of Historic Places, including the Altman House, Beech Street Historic District, James C. Tappan House, Coolidge House, and the Jerome Bonaparte Pillow House. Highway 49B turns south onto Columbia Street, with CRP continuing eastbound on city streets toward the business district, while also intersecting the Great River Road, which runs northbound on Columbia Street and eastbound on Perry Street. US 49B runs south past the Allin House, William Nicholas Straub House, Centennial Baptist Church, and the St. Mary's Catholic Church. The route continues south past the Keesee House, William A. Short House, and Estevan Hall before becoming Biscoe Street and terminating at the parent route.