U.S. Route 45 Alternate (Mississippi)
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| Route information | |
| Length: | 1,297 mi (2,087 km) |
| Existed: | 1926 – present |
| Major junctions | |
| South end: |
 US 98 at Mobile, AL
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  I-43 / I-94 at Milwaukee, WI
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| North end: | Ontonagon and River streets in Ontonagon, MI |
| Location | |
| States: | Alabama, Mississippi, Tennessee, Kentucky, Illinois, Wisconsin, Michigan |
| Highway system | |
I‑65 at Prichard, AL
I-20 / I-59 at Meridian, MS
I-40 at Jackson, TN
I-24 at Paducah, KY
I-57 / I-70 at Effingham, IL
I-80 at Tinley Park, IL
I-55 at Countryside, IL
I-90 at Rosemont, IL
...
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