U.S. Highway 221 in Virginia
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| Route information | ||||
| Maintained by VDOT | ||||
| Length: | 149.61 mi (240.77 km) | |||
| Major junctions | ||||
| South end: |
  US 221 / US 21 near Independence
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 US 501 in Lynchburg
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| North end: |
     US 29 Bus. / US 460 Bus. / US 501 Bus. in Lynchburg
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| Location | ||||
| Counties: | Grayson, City of Galax, Carroll, Floyd, Roanoke, City of Roanoke, Botetourt, Bedford, City of Lynchburg | |||
| Highway system | ||||
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→
US 21 / US 58 in Independence
SR 89 in Galax
I‑77 near Hillsville
US 52 in HillsvilleUS 58 in Hillsville
SR 8 in Floyd
I‑581 / US 220 in Roanoke
US 11 / US 460 in RoanokeUS 460 in Bedford
...
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