Type-III collagen

COL3A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V53, 3DMW, 4AE2, 4AEJ, 4AK3, 4GYX
Identifiers
Aliases	COL3A1, EDS4A, collagen type III alpha 1, collagen type III alpha 1 chain
External IDs	OMIM: 120180 MGI: 88453 HomoloGene: 55433 GeneCards: COL3A1
Gene ontology Molecular function • metal ion binding • integrin binding • protein binding • platelet-derived growth factor binding • SMAD binding • extracellular matrix structural constituent Cellular component • collagen trimer • endoplasmic reticulum lumen • proteinaceous extracellular matrix • extracellular region • collagen type III trimer • extracellular matrix • extracellular space Biological process • positive regulation of Rho protein signal transduction • skeletal system development • negative regulation of neuron migration • response to cytokine • response to mechanical stimulus • aging • extracellular matrix organization • platelet activation • heart development • peptide cross-linking • negative regulation of immune response • blood vessel development • regulation of immune response • cerebral cortex development • collagen catabolic process • cellular response to amino acid stimulus • integrin-mediated signaling pathway • response to radiation • cell-matrix adhesion • digestive tract development • transforming growth factor beta receptor signaling pathway • aorta smooth muscle tissue morphogenesis • skin development • collagen fibril organization • wound healing • supramolecular fiber organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1281	12825
Ensembl	ENSG00000168542	ENSMUSG00000026043
UniProt	P02461	P08121
RefSeq (mRNA)	NM_000090	NM_009930
RefSeq (protein)	NP_000081	NP_034060.2
Location (UCSC)	Chr 2: 188.97 – 189.01 Mb	Chr 1: 45.31 – 45.35 Mb
PubMed search

2V53, 3DMW, 4AE2, 4AEJ, 4AK3, 4GYX

1281

12825

ENSG00000168542

ENSMUSG00000026043

P02461

P08121

NM_000090

NM_009930

NP_000081

NP_034060.2

Collagen alpha-1(III) chain is a protein that in humans is encoded by the COL3A1 gene, which is located on chromosome 2.

Collagen alpha-1(III) chain is a precursor to collagen III, a protein that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.

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