Tymphaea or Tymphaia (Greek: Τυμφαία) was a region in Ancient Greece, specifically Epirus, inhabited by the Tymphaioi, a northwestern Greek tribe that belonged to the Molossian tribal state, or koinon. The region was annexed by and became a province of the Kingdom of Macedon, specifically Upper Macedonia, in the 4th century BC.
Tymphaea and its Greek inhabitants, the Tymphaioi, were named after Mount Tymphe. In circa 350 BC, Tymphaea was conquered by Phillip II (r. 359–336 BC) and incorporated into the Kingdom of Macedon as part of Upper Macedonia. The most famous native of Tymphaea was Polysperchon, a companion of Alexander III (r. 336–323 BC) who later became regent of Macedon in 319 BC; he was the son of Simmias who was the ruler of the Tymphaioi in circa 370 BC.