Two Medicine Creek

Two Medicine River
Amtrak's Empire Builder crosses the Two Medicine River near East Glacier Park in 2011.
Montana rivers with Two Medicine in the north central
Country	Pondera and Glacier County, Montana
Basin features
Main source	48°29′32″N 113°15′49″W / 48.49222°N 113.26361°W / 48.49222; -113.26361 (Two Medicine River)
River mouth	3,294 feet (1,004 m) 48°29′11″N 112°13′40″W / 48.48639°N 112.22778°W / 48.48639; -112.22778 (Two Medicine River)Coordinates: 48°29′11″N 112°13′40″W / 48.48639°N 112.22778°W / 48.48639; -112.22778 (Two Medicine River)
River system	Missouri River

The Two Medicine River is a tributary of the Marias River, approximately 60 mi (97 km) long, in northwestern Montana in the United States.

It rises in the Rocky Mountain Front in Glacier National Park at the continental divide and flows east, down from the mountains and across the Blackfeet Indian Reservation. It receives Birch Creek in southeastern Glacier County and joins Cut Bank Creek to form the Marias, approximately 12 mi (19 km) southeast of Cut Bank.