Tumor necrosis factor receptor 1

TNFRSF1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EXT, 1FT4, 1ICH, 1NCF, 1TNR
Identifiers
Aliases	TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60, tumor necrosis factor receptor superfamily member 1A, TNF receptor superfamily member 1A
External IDs	MGI: 1314884 HomoloGene: 828 GeneCards: TNFRSF1A
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,328,757 bp End 6,342,114 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 F3|6 59.32 cM Start 125,349,362 bp End 125,362,484 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • tumor necrosis factor-activated receptor activity • tumor necrosis factor binding • identical protein binding Cellular component • integral component of membrane • Golgi apparatus • membrane • Golgi membrane • receptor complex • plasma membrane • integral component of plasma membrane • extracellular region • cell surface • mitochondrion • membrane raft • extracellular space Biological process • regulation of apoptotic process • prostaglandin metabolic process • defense response • positive regulation of ceramide biosynthetic process • positive regulation of inflammatory response • regulation of tumor necrosis factor-mediated signaling pathway • tumor necrosis factor-mediated signaling pathway • response to lipopolysaccharide • cellular response to mechanical stimulus • death-inducing signaling complex assembly • regulation of cell proliferation • defense response to bacterium • immune response • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of I-kappaB kinase/NF-kappaB signaling • viral process • I-kappaB kinase/NF-kappaB signaling • negative regulation of inflammatory response • regulation of establishment of endothelial barrier • extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of transcription from RNA polymerase II promoter • signal transduction • apoptotic process • inflammatory response • cell surface receptor signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein • protein localization to plasma membrane • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7132	21937
Ensembl	ENSG00000067182	ENSMUSG00000030341
UniProt	P19438	P25118
RefSeq (mRNA)	NM_001065 NM_001346091 NM_001346092	NM_011609
RefSeq (protein)	NP_001056 NP_001333020 NP_001333021	NP_035739
Location (UCSC)	Chr 12: 6.33 – 6.34 Mb	Chr 12: 125.35 – 125.36 Mb
PubMed search

1EXT, 1FT4, 1ICH, 1NCF, 1TNR

7132

21937

ENSG00000067182

ENSMUSG00000030341

P19438

P25118

NM_001065
NM_001346091
NM_001346092

NM_011609

NP_001056
NP_001333020
NP_001333021

NP_035739

Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα).

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