Tumor necrosis factor alpha

TNF

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW

Identifiers

Aliases

TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, Tumour necrosis factor alpha, TNF-α, tumor necrosis factor, TNLG1F

External IDs

MGI: 104798 HomoloGene: 496 GeneCards: TNF

Gene ontology
Molecular function	• transcription regulatory region DNA binding • protein binding • identical protein binding • protease binding • tumor necrosis factor receptor binding • cytokine activity
Cellular component	• membrane • cell surface • integral component of membrane • recycling endosome • intracellular • integral component of plasma membrane • phagocytic cup • external side of plasma membrane • extracellular region • plasma membrane • membrane raft • extracellular space
Biological process	• regulation of protein phosphorylation • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • response to salt stress • positive regulation of calcidiol 1-monooxygenase activity • positive regulation of programmed cell death • positive regulation of JNK cascade • response to organic substance • negative regulation of osteoblast differentiation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of viral genome replication • humoral immune response • positive regulation of interleukin-8 production • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of protein localization to cell surface • positive regulation of ERK1 and ERK2 cascade • glucose metabolic process • animal organ morphogenesis • apoptotic signaling pathway • negative regulation of alkaline phosphatase activity • regulation of I-kappaB kinase/NF-kappaB signaling • defense response to Gram-positive bacterium • regulation of branching involved in salivary gland morphogenesis • positive regulation of phagocytosis • negative regulation of fat cell differentiation • negative regulation of myoblast differentiation • positive regulation of protein kinase B signaling • regulation of insulin secretion • regulation of immunoglobulin secretion • osteoclast differentiation • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of cytokine secretion • response to virus • positive regulation of osteoclast differentiation • negative regulation of cytokine secretion involved in immune response • positive regulation of peptidyl-serine phosphorylation • negative regulation of branching involved in lung morphogenesis • JNK cascade • death-inducing signaling complex assembly • regulation of osteoclast differentiation • defense response to bacterium • positive regulation of interleukin-6 production • positive regulation of interleukin-8 biosynthetic process • I-kappaB kinase/NF-kappaB signaling • activation of MAPKKK activity • positive regulation of translational initiation by iron • sequestering of triglyceride • positive regulation of chronic inflammatory response to antigenic stimulus • negative regulation of growth of symbiont in host • positive regulation of chemokine (C-X-C motif) ligand 2 production • positive regulation of JUN kinase activity • positive regulation of hair follicle development • chronic inflammatory response to antigenic stimulus • cellular response to organic cyclic compound • positive regulation of fever generation • extracellular matrix organization • positive regulation of sequence-specific DNA binding transcription factor activity • cellular response to nicotine • positive regulation of podosome assembly • regulation of reactive oxygen species metabolic process • positive regulation of protein transport • negative regulation of glucose import • receptor biosynthetic process • activation of MAPK activity • immune response • positive regulation of NFAT protein import into nucleus • leukocyte tethering or rolling • positive regulation of chemokine production • cellular extravasation • negative regulation of lipid storage • negative regulation of myosin-light-chain-phosphatase activity • negative regulation of transcription, DNA-templated • cortical actin cytoskeleton organization • embryonic digestive tract development • leukocyte migration • lipopolysaccharide-mediated signaling pathway • positive regulation of smooth muscle cell proliferation • positive regulation of protein kinase activity • positive regulation of superoxide dismutase activity • defense response • positive regulation of ceramide biosynthetic process • positive regulation of protein complex assembly • protein kinase B signaling • positive regulation of cytokine production • positive regulation of chemokine biosynthetic process • epithelial cell proliferation involved in salivary gland morphogenesis • positive regulation of nitric oxide biosynthetic process • negative regulation of interleukin-6 production • protein import into nucleus, translocation • positive regulation of membrane protein ectodomain proteolysis • positive regulation of humoral immune response mediated by circulating immunoglobulin • positive regulation of interferon-gamma production • response to glucocorticoid • positive regulation of vitamin D biosynthetic process • positive regulation of mononuclear cell migration • positive regulation of NIK/NF-kappaB signaling • MAPK cascade • negative regulation of protein complex disassembly • multicellular organism development • negative regulation of bicellular tight junction assembly • positive regulation of protein complex disassembly • regulation of cell proliferation • cellular response to amino acid stimulus • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • cellular response to lipopolysaccharide • negative regulation of lipid catabolic process • regulation of establishment of endothelial barrier • positive regulation of cell adhesion • regulation of protein secretion • positive regulation of apoptotic process • inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • tumor necrosis factor-mediated signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • necroptotic signaling pathway • positive regulation of gene expression • extrinsic apoptotic signaling pathway • extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of transcription from RNA polymerase II promoter • positive regulation of NF-kappaB transcription factor activity • positive regulation of NF-kappaB import into nucleus • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of leukocyte adhesion to arterial endothelial cell • positive regulation of leukocyte adhesion to vascular endothelial cell • positive regulation of blood microparticle formation • negative regulation of endothelial cell proliferation • positive regulation of heterotypic cell-cell adhesion • negative regulation of mitotic cell cycle • endothelial cell apoptotic process • positive regulation of vascular smooth muscle cell proliferation • negative regulation of gene expression • protein localization to plasma membrane
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7124


21926

Ensembl

ENSG00000228978 ENSG00000230108 ENSG00000223952 ENSG00000204490 ENSG00000228321
ENSG00000232810 ENSG00000228849 ENSG00000206439


ENSMUSG00000024401

UniProt


P01375


P06804

RefSeq (mRNA)


NM_000594


NM_001278601 NM_013693

RefSeq (protein)


NP_000585


NP_001265530 NP_038721

Location (UCSC)

Chr 6: 31.58 – 31.58 Mb

Chr 17: 35.2 – 35.2 Mb

PubMed search

1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW

7124

21926

ENSG00000232810
ENSG00000228849
ENSG00000206439

...
Wikipedia