The Tuira River is located in the Darién Province of eastern Panama. It flows into the Bay of San Miguel at the province capital of La Palma.
It is the largest river in Panama, and one of its tributaries, the Chucunaque River, is the longest river in Panama.
Coordinates: 8°19′10″N 78°18′31″W / 8.3194°N 78.3086°W