Tsegede (sometimes Sagade) is one of the woredas in the Tigray Region of Ethiopia. It is named after the historic province of Tsegede. Part of the Mi'irabawi Zone, Tsegede is bordered on the south and west by the Amhara Region, on the northwest by Kafta Humera, and on the north by Wolqayt. The administrative center of this woreda is Ketema Nigus. Other towns in Tsegede include Dansha and Idaga Hamus.
Tsegede was selected by the Ministry of Agriculture and Rural Development in 2003 as an area for voluntary resettlement for farmers from overpopulated areas. Along with Kafta Humera woreda, the other woreda selected in Tigray that year, this woreda became the home for a total of 7,334 heads of households and 618 total family members. The following year, along with Asigede Tsimbela, this woreda became the home of a total of 24,000 heads of household and a total of 96,000 family members. In 2006, Tsegede was once more selected for this resettlement program, along with Dangila, Lay Armachiho and Qwara in the Amhara Region, becoming the new homes for 8,671 families. This was reportedly accompanied with almost 68 million Birr in infrastructure development.
Based on the 2007 Census conducted by the Central Statistical Agency of Ethiopia (CSA), this woreda has a total population of 103,852, an increase of 59,846 over the 1994 national census, of whom 52,763 are men and 51,089 women. With an area of 4,253.48 square kilometers Tsegede has a population density of 24.42, which is less than the Zone average of 28.94 persons per square kilometer; 9,178 or 8.84% are urban inhabitants. A total of 23,021 households were counted in this woreda, resulting in an average of 4.51 persons to a household, and 21,785 housing units. The majority of the inhabitants said they practiced Ethiopian Orthodox Christianity, with 96.47% reporting that as their religion, while 3.49% of the population were Muslim.