"Trouble Me" is a song by the American alternative rock group 10,000 Maniacs and the first single from their 1989 album Blind Man's Zoo. The single was co-written by the band's then-lead singer, Natalie Merchant, as dedication to her father, Anthony Merchant. "Trouble Me" charted in the both United States and the United Kingdom, becoming a hit for the band. A live version with lead vocalist Mary Ramsey was also included on their 2016 album Playing Favorites.

"Trouble Me", co-written by Dennis Drew and Natalie Merchant, was the first released single of the album. The song was written for Merchant's father, Anthony, who was hospitalized at the time. Gospel singer Jevetta Steele provided the background vocals for the song.

A music video for "Trouble Me" was produced, containing outdoor scenes. Merchant caught a common cold during the filming. It is included in the VHS release 10,000 Maniacs: Time Capsule, Filmed 1982–1990, later re-released on DVD as 10,000 Maniacs: Time Capsule, Filmed 1982–1993.

In the music video, Merchant takes an elderly woman on a bicycle to the place where her friends surprise her and then do activities. In the end, Merchant and the elderly woman ride on a bicycle to a shoreline.

Music critic Anthony DeCurtis wrote that the track "Trouble Me" was "the most uplifting" and "the antidote" to the remainder of the album, which DeCurtis considered "a starkly pessimistic statement."

In the Billboard charts, "Trouble Me" reached number twenty in the Mainstream Rock chart on the week ending July 8, 1989; number three in the Modern Rock Tracks chart on the week ending June 10; number 44 in the Hot 100 chart on the week ending August 12; and number seven in the Adult Contemporary chart on the week ending August 19, 1989. "Trouble Me" reached number 77 in the UK Singles Chart for the week ending June 17, 1989.

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